Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Check. Drugs that raise delta-aminolevulinic acid synthetase may possibly reduce hemin effect.
There are no data on pregnancy exposures in primates equivalent to periods prior to the third trimester in humans.
pentobarbital will minimize the level or effect of tinidazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the extent or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the lower in fentanyl plasma concentrations, not enough efficacy or, quite possibly, progress of the withdrawal syndrome inside of a patient who has developed physical dependence to fentanyl.
Contraindicated (one)pentobarbital will reduce the extent or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Powerful or reasonable CYP3A inducers may well decrease cobimetinib systemic exposure by >80% and lessen its efficacy.
“Around the other hand, the federal government does direct by illustration and to provide the federal government so sharply going in this way is deeply troubling.”
pentobarbital will decrease the level or effect of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unidentified.
pentobarbital will lessen the level or effect of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Fetal blood stages approach maternal blood levels next parenteral administration. Withdrawal symptoms arise in infants born to mothers who obtain barbiturates all through the very last trimester of pregnancy. (See “Drug Abuse and Dependence” portion.) If this drug is used during pregnancy, or if the patient becomes Expecting even though taking this drug, the patient should be apprised in the prospective hazard towards the fetus.
pentobarbital will reduce the extent or effect of efavirenz by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
Sodium valproate and valproic acid show up to lower barbiturate metabolism; hence, barbiturate blood ranges needs to be monitored and proper dosage adjustments made as indicated.
pentobarbital will decrease the level or get more info effect of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Solid or average CYP3A4 inducers may boost fee of diazepam elimination; thus, efficacy of diazepam may be decreased.
pentobarbital will reduce the extent or effect of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will minimize the extent or effect of dutasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.